Chii chinonzi SLU-PP-332 inoshandiswa?

Muchidimbu, iyo ERR agonist SLU-PP-332 inoshanda seyekuita semimetic inducing acute aerobic exercise programme inotungamira kumakumi ezviuru ephysiologic adaptations akabatana nekuita maekisesaizi anosanganisira kuwedzera skeletal muscle oxidative fibers, yakawedzera fatty acid oxidation, uye kuwedzera kurovedza muviri kutsungirira.

Tumira Kubvunza kwako kuti uwane rumwe ruzivo, Tinya email:sales4@faithfulbio.com

Nhepfenyuro shoma

SLU-PP-332 is a synthetic small molecule, ine simba isina-selective estrogen-associated receptor (ERR) agonist, iyo ine simba rakasimba pane ERRα, ine EC50 ye98 nM. Iyo SLU-PP-332 yakamutsa kufarira kwekutsvagisa biomedical nekuda kwekugona kwayo mashandisiro muhutano hwemetabolism uye kuenzanisa kwekuita.

MF: C18H14N2O2

MW: 290.32

CAS: 303760-60-3

Density: 1.20±0.1 g/cm ³ (Zvakafanotaurwa)

Kuchengetedza mamiriro: 2-8°C

Solubility yeDMSO: 2mg/mL, yakajeka (yakadziya)

Acidity coefficient (pKa) : 8.44±0.15(Zvakafanotaurwa)

Mechanism of Action

SLU-PP-332 inoshanda seERRα agonist, inosimudzira mitochondrial basa uye simba metabolism. Inoita basa rakakosha mukugadzirisa mafuta oxidation, glucose metabolism, uye thermogenesis, zvichiita kuti ive mukana wekurapa metabolic kusagadzikana. Mushonga unosungira kune ligand-binding domain yeERRα, ichidzikamisa mashandiro ayo anoshanda uye kuwedzera kudyidzana kwayo nemaprotein ecoactivator, kunyanya PGC-1α (peroxisome proliferator-activated receptor gamma coactivator 1-alpha).

Tsvagiridzo uye Zvikumbiro

SLU-PP-332 yakaedzwa mune dzinoverengeka preclinical zvidzidzo, kusanganisira kugona kwayo: Kuvandudza metabolic syndrome nekusimudzira mitochondrial kunyatsoita. Kurudzira maekisesaizi-mimetic mhedzisiro mune tsandanyama tishu. Reverse age-ane chekuita nemitochondrial dysfunction. SLUPP-332 inogona kusimudzira mitochondrial basa uye kufema kwemasero, kuwedzera rudzi IIa oxidized skeletal muscle fibers, uye kuwedzera kushivirira kwekuita kwe skeletal muscle cell mitsara. SLU-PP-332 ine mukana wekushandiswa mukutsvagisa kwezvirwere zvemetabolism uye kuvandudzwa kwebasa remhasuru, uye inogona zvakare kushandiswa kuvandudza metabolic kusagadzikana uye kuchembera.

Biological Effects

Metabolic Syndrome uye Kufutisa

Zvidzidzo mumhando dzemhuka zvakaratidza kuti SLU-PP-332 inovandudza insulin senitivity uye inoderedza adiposity, ichiratidza kugona kwayo semushonga unorwisa kufutisa. SLU-PP-332 yakagadzirwa:

18-24% kuderedza uremu hwemuviri.

30-35% inoderera muchena adipose tissue mass.

40% kuvandudzwa mukushivirira kweglucose.

25-30% inoderera mukutsanya insulin mazinga.

Kuderera kwakanyanya muhepatic steatosis uye kuzvimba.

Ndezvipi zvinobatsira zveSLU PP?

SLU-PP-332 mushonga unotevedzera mhedzisiro yekurovedza muviri, inotungamira kune yakawedzera simba rekushandisa uye padyo nemafuta emuviri metabolism. kurovedza muviri kutanga. Uyu mumiririri anonatsiridza nzira yechisikigo yemetabolism inoenderana nekuita maekisesaizi, zvichikonzera kushandiswa kwesimba rakawedzerwa, uye mamwe mafuta emuviri metabolism.

SLU-PP-332 inoshanda here?

Tsvagiridzo yekutanga yakanangana neakajairwa-huremu mbeva uye yakaratidza zvimwe zvinokatyamadza mhedzisiro. Mbeva dzakabatwa neSLU-PP-332 dzakakwanisa kumhanya 70% kureba uye 45% mberi kupfuura vamwe vavo vasina kurapwa. Zvakafanana nekubva pakungoita kutenderedza chivharo kusvika kamwe kamwe kugadzirira hafu-marathon!

Ndezvipi mhedzisiro yeSLU-PP-332?

Zvinogona kuitika: Migumisiro inocherechedzwa inosanganisira nyoro hyperthermia, kuwedzera kwemwoyo, uye kuchinja kwechinguva mumakemikari echiropa muzvidzidzo zvemhuka.

Yakawanda sei SLU-PP-332?

Ndapota tiudzei kero yakadzama yekutumira kuitira kuti tigokutumirai mari yekutumira.

Tumira Kubvunza kwako kuti uwane rumwe ruzivo, Tinya email:sales4@faithfulbio.com

Ramangwana Mirairo

Tsvagiridzo paSLU-PP-332 uye yakabatana ERR modulators inoenderera mberi ichiwedzera munzvimbo nyowani dzekurapa:

Neurodegeneration: Zvidzidzo zvekutanga zvinoratidza zvinogona kushandiswa muAlzheimer's uye Parkinson's hosha kuburikidza nekuvandudzwa kwemitochondrial basa.

Cancer metabolism: Kuferefeta basa rekusaina ERR mune tumor energetics uye inogona kurapa kurapa.

Tsvagiridzo yehupenyu hurefu: Kuongorora kweERR activation seyanogona kupindira kuwedzera hutano.

Mushonga wakasarudzika nzira: Kukudziridzwa kwema biomarkers kuona varwere vangango pindura kune ERR-yakanangwa marapirwo.

1. Une dambudziko here kuendesa kunyika yangu?

A: Tine matura muEurope, America neAustralia. Panguva imwecheteyo, kana uchibva kuEurope, zvinhu zvinogona kutumirwa kubva kuGermany, uye kana uchibva kuAmerica kana kuCanada, zvinhu zvinogona kutumirwa kubva kuCalifornia.

2. Zvinhu zvinorongedzerwa sei?

A: Isu tinowanzo tumira zvinhu zvine disguise package kunze uye kaviri-layer sterile transparent bag mukati.Takaedza zviuru zvepasuru nzira, inotaridzika yakakomba uye yakangwara.

3. Iwe uchatumira rinhi zvinhu mushure mekubhadhara kwakabudirira?

A: Kazhinji kurongeka kuchave kuendeswa mukati memazuva 2-3 mushure mekunge odha yasimbiswa, kunze kwezvakagadzirirwa zvigadzirwa.

4. Nzira yekuenderera mberi sei?

A: Ndapota Rega ndikuzivise chigadzirwa chauri kutsvaga, huwandu uye nyika yekwauri kundibatsira kukupa mutengo wakakodzera; Mushure mekunge wasimbisa zvese zveodha, bhadhara mari isati yasvika uye utipe Kutumira kero.

Tumira Kubvunza kwako kuti uwane rumwe ruzivo, Tinya email:sales4@faithfulbio.com