Chii chinoita 5 Amino 1MQ?
The 5-Amino-1MQ komboni, iyo idiki, inosarudza, uye inogona kupfuura nepakati pesero membranes, inotarisira kukanganisa chaiwo maseru masisitimu anodzora kuchengetwa kwemafuta, kukura kwemhasuru, uye metabolism. Masayendisiti akatanga kugadzira 5-Amino-1MQ yekudzidza nzira dzemetabolism dzakabatana nekufutisa uye matambudziko ane chekuita nezera.
Tumira Kubvunza kwako kuti uwane rumwe ruzivo, Tinya email:sales4@faithfulbio.com
Nhepfenyuro shoma
"5-Amino-1MQ (NNMTi)" iri peptide inogona kuwedzera simba remuviri uye inoshanda pakupisa mafuta uye kuparara kwemafuta. Chikonzero nei "5-Amino-1MQ" ichishanda pakudya ndechekuti inogona kuwedzera huwandu hweNAD (nicotinamide adenine dinucleotide), uye NAD chinhu chakakosha kuchengetedza hutano hwesero uye mabasa mumuviri. NNMTi inhibitor inoshanda ye nicotinamide N-methyltransferase (NNMT) (IC50 = 1.2μM), uye inogona kusarudza kusunga kune zvakasara panzvimbo yeNNMT substrate inosunga. NNMTi inogona kukurudzira kusiyanisa kwemyoblasts in vitro uye kuwedzera fusion uye kuberekwa patsva kwemasero emhasuru stem mumakonzo akwegura.
Nzvimbo yakanyunguduka: 213-214 ° C
Molecular formula: C10H11IN2
Molecular weight: 286.11
Kugadzirira nzira
5-Amino-1Mq idiki molecule inhibitor ye nicotinamide N-methyltransferase (NNMT), iyo yakadzidzwa zvakanyanya mumakore achangopfuura. Nezve gadziriro yechinhu ichi, pane kunyanya nzira mbiri dzekugadzira dzinotaurwa muzvinyorwa zvazvino: Imwe ndeyekuita kwakananga kwe5-Aminoquinoline neIodomethane muIsopropyl doro. Kuipa kwekuita uku ndiko kuderera kwegoho. Imwezve ndeyekuita kwe5-Aminoquinoline uye Iodomethane kuumba 5-Amino-1Mq, iyo inobva yawanikwa kuburikidza nekuderedza nehupfu hwesimbi. Kuipa kwekuita uku ndiko kuti kubviswa kwechigadzirwa kwakaoma, uye huwandu hwemvura yakasviba hwakakura, zvichikonzera kusvibiswa kwakakomba kwezvakatipoteredza. Naizvozvo, zvinonyanya kukosha kuongorora maitiro ekugadzira akasvibira, ane hushamwari kwezvakatipoteredza, ari nyore kushanda, ane hupfumi uye akachengeteka.
Tichifunga nezvekushayikwa kweiyo tekinoroji iripo, kugadzirwa kwezvino kunopa nzira yekubatanidza ye5-Amino-1Mq, kusanganisira matanho anotevera: Wedzera 5-Aminoquinoline uye mhinduro inonyungudika kune reactor uye kumutsa; Dissolve Iodomethane mune reaction solvent, wedzera kudonha kune reactor. Mushure mekuwedzera kwedonhwe kwapera, wedzera tembiricha uye chengetedza tembiricha yekupindura, wobva watonhorera pasi uye ramba uchizunza, kusefa, uye sukurudza keke resefa nekashoma kekunyungudika. Mushure mekuchenesa keke yesefa, yakashambidzwa uye yakaomeswa kuti iwane tsvuku-tsvuku yakasimba. Muchigadzirwa ichi, chinangwa chechigadzirwa chakawanikwa kuburikidza nekuita kwakananga kwe5-Aminoquinoline uye Iodomethane. Nekukwenenzvera mamiriro ekuita, zvirimo zvechigadzirwa chakanangwa muhurongwa hwekuita zvakawedzerwa, uye mamiriro ekuchenesa echigadzirwa akaongororwa. Ita kuchena kwe5-Amino-1Mq inogona kusvika kupfuura 99%.
Kutsvaga kwakabatana
Kufutisa idambudziko rakakura uye riri kuramba richikura rehutano pasi rose, uye kune nzira shoma dzekurapa dzinoshanda. Chidzidzo ichi chakaongorora mabhenefiti uye emuviri mabhenefiti ekusanganiswa kwe5-Amino-1Mq (NNMTi) kurapwa uye kutsiva kwekudya mukudya-induced obese mice. Kuenzaniswa nekungovandudza kudya, 5-Amino-1Mq kurapwa kwakasanganiswa nekutsiviwa kwechikafu kunogona kukurumidza nekuvandudza uremu uye kurasikirwa kwemafuta, kuwedzera chiyero chemuviri wakaonda kune uremu hwemuviri, kuderedza huremu hwewhite adipose tishu muchiropa uye epididymis, kuderedza kufutisa kwechiropa, uye kugadzirisa chiropa steatosis kuburikidza nekutsiviwa kwega. Zvakakosha, musanganiswa wezviviri izvi zvinogona kudzoreredza kuumbwa kwemuviri uye chiropa kufutisa paramita. 5-Amino-1Mq kurapwa yakagadzira yakasarudzika metabolomic maitiro muadipose tishu, kunyanya kuwedzera kuwanda kweketogenic amino acids uye shanduko mumatabolites ane chekuita nesimba metabolism nzira. Zvese mune zvese, kudzorwa kwehuremu hwemuviri, kufutisa, chiropa physiology uye adipose tishu metabolome ne5-Amino-1Mq kurapwa inotsigira zvakasimba iyo seanovimbisa kurapwa nzira yekufutisa uye kufutisa-induced complications.
Uyezve, 5-Amino-1Mq (NNMTi) inogonawo kuwedzera simba uye kusimudzira kukwanisa kudzoreredza kwemhasuru dzekuchembera, nekudaro ichipa nzira inovimbisa yekurapa sarcopenia. Zvidzidzo zvakaratidza kuti 5-Amino-1Mq kurapwa haingogone kukurudzira quantifiable kuvandudzwa kweiyo lipid yemukati mumaseru masero, asiwo zvakanyanya kuwedzera gastrocnemius tsandanyama fiber kana yasanganiswa nekurovedza muviri. Mishonga yakavakirwa pa5-Amino-1Mq, ingave yakashandiswa yoga kana musanganiswa nekurovedza muviri, ichave inobatsira pakurapa sarcopenia uye akasiyana-siyana ane hukama nezera myopathies.
Chii chinonzi 5 amino 1MQ yekuwedzera?
5-Amino-1MQ imorekuru diki rine mukana wakakosha muminda yehutano uye hutano. Inotsanangurwa seyakatorwa kubva kumethylquinolinium. Iyi yakasarudzika peptide-yakaita sekomboni yakawana kutariswa nebasa rayo mukutsigira metabolism, huremu huremu, uye cellular kugadzirwa kwesimba.
Is 5 Amino 1MQ side effect?
Pane maside effects here? Chero mishonga inogona kuve nemhedzisiro, asi iyo ye5 Amino 1MQ ishoma. Mikoko kana allergic reactions zvinogoneka neiyi peptide.
1. Une dambudziko here kuendesa kunyika yangu?
A: Tine matura muEurope, America neAustralia. Panguva imwecheteyo, kana uchibva kuEurope, zvinhu zvinogona kutumirwa kubva kuGermany, uye kana uchibva kuAmerica kana kuCanada, zvinhu zvinogona kutumirwa kubva kuCalifornia.
2. Zvinhu zvinorongedzerwa sei?
A: Isu tinowanzo tumira zvinhu zvine disguise package kunze uye kaviri-layer sterile transparent bag mukati.Takaedza zviuru zvepasuru nzira, inotaridzika yakakomba uye yakangwara.
3. Iwe uchatumira rinhi zvinhu mushure mekubhadhara kwakabudirira?
A: Kazhinji kurongeka kuchave kuendeswa mukati memazuva 2-3 mushure mekunge odha yasimbiswa, kunze kwezvakagadzirirwa zvigadzirwa.
4. Nzira yekuenderera mberi sei?
A: Ndapota Rega ndikuzivise chigadzirwa chauri kutsvaga, huwandu uye nyika yekwauri kundibatsira kukupa mutengo wakakodzera; Mushure mekunge wasimbisa zvese zveodha, bhadhara mari isati yasvika uye utipe Kutumira kero.
Tumira Kubvunza kwako kuti uwane rumwe ruzivo, Tinya email:sales4@faithfulbio.com
